The present study was designed to assess the effect of methanolic and aqueous extracts of Oroxylum indicum (family: Bignoniaceae) leaves in alloxan-treated diabetic rats. The leaves of Oroxylum indicum were extracted using methanol by soxhlation and water by maceration process. The extracts were evaluated for acute toxicity in mice. Diabetes mellitus was induced by intraperitoneal injections of alloxan (120 mg/kg). The diabetic animals were orally treated with methanolic and aqueous extracts (300 mg/kg b.wt.) for 21 days. Glibenclamide was used as a reference drug at a dose of 10 mg/kg b.w. Fasting blood glucose level, lipid profile, biomarkers enzymes, serum total proteins, serum creatinine and serum urea were evaluated in normal and diabetic rats. The 21-day treatment with extracts resulted in significant decrease in blood glucose level. Elevated serum glutamate oxaloacetate transaminase (SGOT), glutamate pyruvate transaminase (SGPT), and alkaline phosphatase (SALP) were diminished significantly by the treatment of methanolic and aqueous extract in respect to diabetic group. Also there was significant decrease in serum triglyceride, total cholesterol, protein, urea and creatinine levels in treated groups. The methanol extract induced more significant antidiabetic effect than the aqueous extract.
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